Studies on adrenocorticotropic hormone receptor using isolated rat adrenocortical cells.
نویسندگان
چکیده
منابع مشابه
Adrenocortical Response in Cows after Injection of Adrenocorticotropic Hormone
Adrenocorticotropic hormone (ACTH) challenge test is recognized as a method for evaluating some forms of stress. Six lacting cows, well trained to blood sampling were used for this study. Cows were randomly assigned to receive saline or an intramuscular single dose (0.5 μg/kg) of ACTH (Synacthen Depot). Blood samples (10 mL) were collected from the coccygeal blood vessels of all cows at 0 h (im...
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A study of bovine adrenocortical cell shape on adrenocorticotropic hormone (ACTH) challenge showed that the cells round up and develop arborized processes. This effect was found to be (1) specific for ACTH because angiotensin II and basic fibroblast growth factor have no effect; (2) mediated by a cAMP-dependent pathway because forskolin reproduces the effect of the hormone; (3) inhibited by sod...
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It has been demonstrated that adrenocorticotropic hormone (ACTH) stimulates isolated, perfused adrenal glands (1) and adrenocortical tissue slices (2, 3) to release increased quantities of corticosteroid hormones. These findings are in accord with the well established fact that ACTH in tivo causes the adrenal cortex to secrete increased quantities of the adrenal steroid hormones. The present wo...
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With a trypsin digestion method, an isolated adrenocortical carcinoma cell preparation has been achieved. The electron microscopic examination of tumor cells shows the sparsity of the lipid granules and mitochondria. The cristae of the mitochondria are tubular, in contrast to the vesicular cristae in the normal cells. Other ultrastructural features of these cells are presented. The adrenocortic...
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Adrenocortical carcinoma tissue removed from a mildly hirsute 16-year-old girl was cultured in order to assess steroidogenesis and responsiveness of the cells to adrenocorticotropic hormone (ACTH), human chorionic gonadotropin (HCG), and insulin. The cells in culture produced large amounts of androstenedione and testosterone; however, production of cortisol, which was initially high, decreased ...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1978
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.25.545